News Hungary Miskolc: University of Miskolc, Hungary
The Nature Index tracks the affiliations of scientific articles from high-quality publications. The research profile for University of Miskolc reflects the research output of authors from University of Miskolc who published articles in the 145 journals included in the Nature Index during the current 12-month rolling window.
News Hungary Miskolc: 13 people, including children, injured in a crash involving a Slovak bus in Hungary
Ten children and three adults were injured on the evening of June 12 after a bus crashed into a car in northeastern Hungary. The bus with Slovak licence ... They were all transported to the hospital ...
News Hungary Miskolc: Miskolctapolca restaurant wins Italian chamber award
The Avalon Ristorante in Miskolctapolca (183 km northeast of Budapest, close to the city of Miskolc) has become the first Italian restaurant outside of the capital to receive the Marchio Ospitalità Italiana award, according to the Italian Chamber of Commerce for Hungary (CCIU).
News Hungary Miskolc: Grieving fiancee of Edinburgh dad who took own life sets up mental health group
Labourer Mr Jeles, 31, originally from Miskolc, Hungary lived in Macgill Drive, Muirhouse with his young fiancee Louise Hamilton, 32, two stepchildren Zach, ten, Nathan, six and nine week old twin ...
News Hungary Miskolc: Hungary’s ‘Slave Law’ Has Sparked Nationwide Protests
Doszpoly, in Miskolc, told me he doesn’t think he’s seeing anybody ... To understand why these protests could be a milestone, it’s important to know a bit about how Hungary got into this mess in the ...
News Hungary Miskolc: Miskolc, Hungary 10 Day Weather
<img class="styles__noscript__2rw2y" src="https://dsx.weather.com//util/image/w/ba8f6c2f-3131-49bd-9474-a75c29dd0788_815x458.jpg?v=at&w=1280&h=720&api=7db9fe61-7414-47b5-9871-e17d87b8b6a0" ...
News Hungary Miskolc: Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice
Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice Erik Őrfi,1,2 Tamás Mészáros,1,2 Mark Hennies,3 Tamás Fülöp,1,2 László Dézsi,1,2 Alexander Nardocci,1 László Rosivall,1,2 Péter Hamar,4,5 Barry W Neun,6 Marina A Dobrovolskaia,6 János Szebeni,1,2,7,* Gábor Szénási1,8,* 1Nanomedicine Research and Education Center, Institute of Pathophysiology, Semmelweis University, Budapest, Hungary; 2SeroScience LCC., Cambridge, MA, USA; 3TECOdevelopment GmbH, Rheinbach, Germany; 4Institute of Clinical Experimental Research, Semmelweis University, Budapest, Hungary; 5Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; 6Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA; 7Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary; 8Institute of Pathophysiology, Semmelweis University, Budapest, Hungary *These authors contributed equally to this work Purpose: Undesirable complement (C) activation by nanomedicines can entail an adverse immune reaction known as C activation-related pseudoallergy (CARPA) in sensitive patients. The syndrome includes cardiopulmonary, hemodynamic, and a variety of other physiological changes that have been well described in man, pigs, dogs, and rats. However, the information on CARPA is scarce and ambiguous in mice, a species widely used in preclinical studies. The present study aimed to fill this gap by exploring signs of CARPA in mice following i.v. administration of AmBisome and Abelcet, which are nano-formulations of Amphotericin B with high risk to cause CARPA. Materials and methods: Anesthetized NMRI mice were intravenously injected with liposomal amphotericin B (Abelcet and AmBisome; 30–300 mg phospholipid/kg), drug-free high cholesterol multilamellar vesicles (HC-MLV), and positive controls, cobra venom factor (CVF) and zymosan, followed by the measurement of blood pressure (BP), heart rate, white blood cell, and platelet counts and plasma thromboxane B2 (TXB2) levels. C activation was assessed by C3a ELISA, a C3 consumption assay (PAN-C3) and a modified sheep red blood cell hemolytic assay. Results: All test agents, except HC-MLV, caused transient hypertension, thrombocytopenia, and elevation of plasma TXB2, which were paralleled by significant rises of plasma C3a in CVF and zymosan-treated animals, wherein the initial hypertension turned into hypotension and shock. Abelcet and AmBisome caused minor, delayed rise of C3a that was not associated with hypertension. The C3a receptor inhibitor SB-290157 attenuated the hypertension caused by Abelcet and decreased the BP thereafter. Conclusion: The parallelism between C3a anaphylatoxin production and severity of physiological changes caused by the different agents is consistent with CARPA underlying these changes. Although the reactive dose of liposomal phospholipids was substantially higher than that in other species (pigs, dogs), the mouse seems suitable for studying the mechanism of hypersensitivity reactions to liposomal formulations of amphotericin B, a frequent side effect of these drugs. Keywords: hypersensitivity, infusion reactions, zymosan, cobra venom factor, TXB2, cholesterol, anaphylatoxins, platelets
News Hungary Miskolc: German group boosts Hungarian headcount by 30%
Leadec is one of the leading providers of technical services in the industry. Its revenues reached EUR 900 million in 2017. In Hungary, Leadec is currently present in Győr, Kecskemét, Miskolc, ...
News Hungary Miskolc: Hungary hit by strikes in public sector and auto industry
Hungary is currently being hit by a wave of strikes ... supported their demand for more wages by holding a protest strike. At a Bosch Group plant in Miskolc, the ETMOSz union organized a protest ...
News Hungary Miskolc: What I learned about Viktor Orbán on a road trip with my dad
And in two young female artists who had moved back to Miskolc in the hope of sparking cultural regeneration. By no means were all these people either devoted fans of Orbán or his version of ...
News Hungary Miskolc: Lufthansa Technik to Open Hungarian Component Repair Facility
Lufthansa Technik has unveiled plans to establish a new facility in Hungary where it will offer repair and overhaul services on aircraft engine parts. Located in the city of Miskolc in northeastern ...
News Hungary Miskolc: Hotels in Miskolc
What is the average price per night in Miskolc in April? We use indicative prices on this page to help you choose from a large number of options. This month's estimated lowest price is based on the ...
News Hungary Miskolc: Miskolc Airport, Miskolc, Hungary [ MCQ / LHMC ]
Looking for information on Miskolc Airport, Miskolc, Hungary? Know about Miskolc Airport in detail. Find out the location of Miskolc Airport on Hungary map and also find out airports near to Miskolc. ...
